3WEE

Structure of the full-length yeast Arp7-Arp9 Heterodimer

3WEE の概要

• エントリーDOI: 10.2210/pdb3wee/pdb
• 分子名称: Actin-like protein ARP9, Actin-related protein 7, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: actin, chromatin, remodeling, rsc complex, swi-snf complex, nucleus, arp, actin-related protein, actin-like protein, transcription regulator
• 由来する生物種: Saccharomyces cerevisiae (Baker's yeast); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 111006.37

構造登録者

Lobsiger, J.,Richmond, T.J. (登録日: 2013-07-06, 公開日: 2014-02-26, 最終更新日: 2024-10-30)

主引用文献

Lobsiger, J.,Hunziker, Y.,Richmond, T.J.
Structure of the full-length yeast Arp7-Arp9 heterodimer.
Acta Crystallogr.,Sect.D, 70:310-316, 2014

PubMed Abstract: The nuclear actin-related proteins Arp7 and Arp9 are components of the yeast SWI/SNF and RSC chromatin-remodelling complexes. The 3.1 Å resolution crystal structure reported here shows that the full-length Arp7 and Arp9 proteins exist as a dimer without a requirement for additional polypeptides. Of the 11 actin-related proteins, Arp7 and Arp9 are the only two directly demonstrated to form a dimer within this family. The Arp7-Arp9 heterodimer is unlikely to form an actin-like filament based on modelling using the structure. The Arp7-Arp9 structure reveals that its dimerization interface is not altered when bound in a complex with the SWI/SNF Snf2 HSA domain and the regulatory protein Rtt102.

PubMed: 24531465
DOI: 10.1107/S1399004713027417

実験手法

X-RAY DIFFRACTION (3.1 Å)