3WD9

Crystal structure of phosphodiesterase 4B in complex with compound 10f

3WD9 の概要

• エントリーDOI: 10.2210/pdb3wd9/pdb
• 分子名称: cAMP-specific 3',5'-cyclic phosphodiesterase 4B, 4-[(4-{2-[(2,2-dimethylpropyl)amino]-2-oxoethyl}phenyl)amino]-2-phenylpyrimidine-5-carboxamide, ZINC ION, ... (5 entities in total)
• 機能のキーワード: phosphodiesterase, copd, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 87751.29

構造登録者

Takahashi, M.,Hanzawa, H. (登録日: 2013-06-11, 公開日: 2013-10-23, 最終更新日: 2023-11-08)

• 主引用文献: Goto, T.,Shiina, A.,Yoshino, T.,Mizukami, K.,Hirahara, K.,Suzuki, O.,Sogawa, Y.,Takahashi, T.,Mikkaichi, T.,Nakao, N.,Takahashi, M.,Hasegawa, M.,Sasaki, S.; Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors; Bioorg.Med.Chem., 21:7025-7037, 2013; PubMed: 24094436; DOI: 10.1016/j.bmc.2013.09.013

実験手法

X-RAY DIFFRACTION (2.5 Å)