3W8Q
Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1)
Summary for 3W8Q
| Entry DOI | 10.2210/pdb3w8q/pdb |
| Descriptor | Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER (3 entities in total) |
| Functional Keywords | transferase, nucleotide-binding, phosphorylation |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: Q02750 |
| Total number of polymer chains | 1 |
| Total formula weight | 39760.38 |
| Authors | Nakae, S.,Kitamura, M.,Shirai, T.,Tada, T. (deposition date: 2013-03-20, release date: 2014-03-26, Last modification date: 2021-12-22) |
| Primary citation | Nakae, S.,Kitamura, M.,Fujiwara, D.,Sawa, M.,Shirai, T.,Fujii, I.,Tada, T. Structure of mitogen-activated protein kinase kinase 1 in the DFG-out conformation. Acta Crystallogr.,Sect.F, 77:459-464, 2021 Cited by PubMed: 34866601DOI: 10.1107/S2053230X21011687 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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