3W6A

Crystal structure of cross-linked tetragonal hen egg white lysozyme soaked wiht 5mM [Ru(benzene)Cl2]2

3W6A の概要

• エントリーDOI: 10.2210/pdb3w6a/pdb
• 関連するPDBエントリー: 4J7V
• 分子名称: Lysozyme C, CHLORIDE ION, SODIUM ION, ... (7 entities in total)
• 機能のキーワード: hydrolase
• 由来する生物種: Gallus gallus (chicken)
• 細胞内の位置: Secreted: P00698
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14906.16

構造登録者

Tabe, H.,Abe, S.,Hikage, T.,Kitagawa, S.,Ueno, T. (登録日: 2013-02-13, 公開日: 2014-02-19, 最終更新日: 2024-11-20)

主引用文献

Tabe, H.,Abe, S.,Hikage, T.,Kitagawa, S.,Ueno, T.
Porous protein crystals as catalytic vessels for organometallic complexes.
Chem Asian J, 9:1373-1378, 2014

PubMed Abstract: Porous protein crystals, which are protein assemblies in the solid state, have been engineered to form catalytic vessels by the incorporation of organometallic complexes. Ruthenium complexes in cross-linked porous hen egg white lysozyme (HEWL) crystals catalyzed the enantioselective hydrogen-transfer reduction of acetophenone derivatives. The crystals accelerated the catalytic reaction and gave different enantiomers based on the crystal form (tetragonal or orthorhombic). This method represents a new approach for the construction of bioinorganic catalysts from protein crystals.

PubMed: 24677803
DOI: 10.1002/asia.201301347

実験手法

X-RAY DIFFRACTION (1.77 Å)