3W5E
Crystal structure of phosphodiesterase 4B in complex with compound 31e
Summary for 3W5E
Entry DOI | 10.2210/pdb3w5e/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4B, N-tert-butyl-2-{4-[(5,5-dioxido-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl}acetamide, ZINC ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, copd, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 87845.45 |
Authors | Takahashi, M.,Hanzawa, H. (deposition date: 2013-01-28, release date: 2013-05-29, Last modification date: 2023-11-08) |
Primary citation | Goto, T.,Shiina, A.,Yoshino, T.,Mizukami, K.,Hirahara, K.,Suzuki, O.,Sogawa, Y.,Takahashi, T.,Mikkaichi, T.,Nakao, N.,Takahashi, M.,Hasegawa, M.,Sasaki, S. Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors Bioorg.Med.Chem.Lett., 23:3325-3328, 2013 Cited by PubMed: 23602400DOI: 10.1016/j.bmcl.2013.03.104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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