3W33

EGFR kinase domain complexed with compound 19b

3W33 の概要

• エントリーDOI: 10.2210/pdb3w33/pdb
• 関連するPDBエントリー: 3POZ 3W32
• 分子名称: Epidermal growth factor receptor, 4-{[4-(1-benzothiophen-4-yloxy)-3-chlorophenyl]amino}-N-(2-hydroxyethyl)-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: anti-oncogene, cell cycle, disease mutation, kinase domain, receptor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38167.51

構造登録者

Sogabe, S.,Kawakita, Y. (登録日: 2012-12-07, 公開日: 2013-03-06, 最終更新日: 2023-11-08)

• 主引用文献: Kawakita, Y.,Seto, M.,Ohashi, T.,Tamura, T.,Yusa, T.,Miki, H.,Iwata, H.,Kamiguchi, H.,Tanaka, T.,Sogabe, S.,Ohta, Y.,Ishikawa, T.; Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors; Bioorg.Med.Chem., 21:2250-2261, 2013; PubMed: 23490150; DOI: 10.1016/j.bmc.2013.02.014

実験手法

X-RAY DIFFRACTION (1.7 Å)