3W2T

Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with vildagliptin

3W2T の概要

• エントリーDOI: 10.2210/pdb3w2t/pdb
• 分子名称: Dipeptidyl peptidase 4, beta-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: alpha/beta, beta-propeller, hydrolase, aminopeptidase, serine protease, secreted, signal-anchor, transmembrane, diabetes, glycoprotein, cell membrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 176942.22

構造登録者

Kishida, H.,Nabeno, M.,Miyaguchi, I.,Tanaka, Y.,Katou, R.,Akahoshi, F. (登録日: 2012-12-04, 公開日: 2013-05-15, 最終更新日: 2023-11-08)

• 主引用文献: Nabeno, M.,Akahoshi, F.,Kishida, H.,Miyaguchi, I.,Tanaka, Y.,Ishii, S.,Kadowaki, T.; A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site; Biochem.Biophys.Res.Commun., 434:191-196, 2013; PubMed: 23501107; DOI: 10.1016/j.bbrc.2013.03.010

実験手法

X-RAY DIFFRACTION (2.36 Å)