3W2C

Structure of Aurora kinase A complexed to benzoimidazole-indazole inhibitor XV

Summary for 3W2C

• Entry DOI: 10.2210/pdb3w2c/pdb
• Descriptor: Aurora kinase A, 2-{4-[3-(1H-benzimidazol-2-yl)-1H-indazol-6-yl]-1H-pyrazol-1-yl}-N-(3-methylbutyl)acetamide (3 entities in total)
• Functional Keywords: kinase, atp competitor, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: O14965
• Total number of polymer chains: 4
• Total formula weight: 122945.30

Authors

Oliveira, T.M.,Kairies, N.A.,Engh, R.A. (deposition date: 2012-11-28, release date: 2014-02-05, Last modification date: 2024-03-20)

• Primary citation: Oliveira, T.M.,Kairies, N.,Engh, R.A.; Flexibility and multiple conformations of the activation and glycine rich loops of aurora A accompanying inhibitor binding; To be Published,

Experimental method

X-RAY DIFFRACTION (2.45 Å)