3W2C

Structure of Aurora kinase A complexed to benzoimidazole-indazole inhibitor XV

3W2C の概要

• エントリーDOI: 10.2210/pdb3w2c/pdb
• 分子名称: Aurora kinase A, 2-{4-[3-(1H-benzimidazol-2-yl)-1H-indazol-6-yl]-1H-pyrazol-1-yl}-N-(3-methylbutyl)acetamide (3 entities in total)
• 機能のキーワード: kinase, atp competitor, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: O14965
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 122945.30

構造登録者

Oliveira, T.M.,Kairies, N.A.,Engh, R.A. (登録日: 2012-11-28, 公開日: 2014-02-05, 最終更新日: 2024-03-20)

• 主引用文献: Oliveira, T.M.,Kairies, N.,Engh, R.A.; Flexibility and multiple conformations of the activation and glycine rich loops of aurora A accompanying inhibitor binding; To be Published,

実験手法

X-RAY DIFFRACTION (2.45 Å)