3W01

Crystal structure of PcrB complexed with PEG from Staphylococcus aureus subsp. aureus Mu3

3W01 の概要

• エントリーDOI: 10.2210/pdb3w01/pdb
• 関連するPDBエントリー: 3VZX 3VZY 3VZZ 3W00 3W02
• 分子名称: Heptaprenylglyceryl phosphate synthase, TRIETHYLENE GLYCOL (3 entities in total)
• 機能のキーワード: biosynthesis, prenyltransferases, enzyme catalysis, transferase
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 52555.83

構造登録者

Ren, F.,Feng, X.,Ko, T.P.,Huang, C.H.,Hu, Y.,Chan, H.C.,Liu, Y.L.,Wang, K.,Chen, C.C.,Pang, X.,He, M.,Li, Y.,Oldfield, E.,Guo, R.T. (登録日: 2012-10-17, 公開日: 2012-12-26, 最終更新日: 2023-11-08)

主引用文献

Ren, F.,Feng, X.,Ko, T.P.,Huang, C.H.,Hu, Y.,Chan, H.C.,Liu, Y.L.,Wang, K.,Chen, C.C.,Pang, X.,He, M.,Li, Y.,Oldfield, E.,Guo, R.T.
Insights into TIM-barrel prenyl transferase mechanisms: crystal structures of PcrB from Bacillus subtilis and Staphylococcus aureus
Chembiochem, 14:195-199, 2013

PubMed Abstract: Well structured: As a new triose phosphate isomerase (TIM) barrel-fold prenyl transferase, PcrB catalyzes the production of heptaprenylglyceryl phosphate from heptaprenyl diphosphate and glycerol-1-phosphate. Crystal structures of PcrB from Bacillus subtilis and Staphylococcus aureus in complex with ligands were solved, and together with site-directed mutagenesis and bioinformatics analyses, clearly reveal the catalytic mechanism of the enzyme.

PubMed: 23322418
DOI: 10.1002/cbic.201200748

実験手法

X-RAY DIFFRACTION (1.54 Å)