3W00
Crystal structure of PcrB complexed with G1P and FsPP from bacillus subtilis subap. subtilis str. 168
Summary for 3W00
| Entry DOI | 10.2210/pdb3w00/pdb |
| Related | 3VZX 3VZY 3VZZ 3W01 3W02 |
| Descriptor | Heptaprenylglyceryl phosphate synthase, PHOSPHATE ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, ... (5 entities in total) |
| Functional Keywords | biosynthesis, prenyltransferases, enzyme catalysis, transferase |
| Biological source | Bacillus subtilis |
| Total number of polymer chains | 2 |
| Total formula weight | 50886.69 |
| Authors | Ren, F.,Feng, X.,Ko, T.P.,Huang, C.H.,Hu, Y.,Chan, H.C.,Liu, Y.L.,Wang, K.,Chen, C.C.,Pang, X.,He, M.,Li, Y.,Oldfield, E.,Guo, R.T. (deposition date: 2012-10-17, release date: 2012-12-26, Last modification date: 2023-11-08) |
| Primary citation | Ren, F.,Feng, X.,Ko, T.P.,Huang, C.H.,Hu, Y.,Chan, H.C.,Liu, Y.L.,Wang, K.,Chen, C.C.,Pang, X.,He, M.,Li, Y.,Oldfield, E.,Guo, R.T. Insights into TIM-barrel prenyl transferase mechanisms: crystal structures of PcrB from Bacillus subtilis and Staphylococcus aureus Chembiochem, 14:195-199, 2013 Cited by PubMed Abstract: Well structured: As a new triose phosphate isomerase (TIM) barrel-fold prenyl transferase, PcrB catalyzes the production of heptaprenylglyceryl phosphate from heptaprenyl diphosphate and glycerol-1-phosphate. Crystal structures of PcrB from Bacillus subtilis and Staphylococcus aureus in complex with ligands were solved, and together with site-directed mutagenesis and bioinformatics analyses, clearly reveal the catalytic mechanism of the enzyme. PubMed: 23322418DOI: 10.1002/cbic.201200748 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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