3VPK

Crystal Structure of 6-Guanidinohexanoyl Trypsin

Summary for 3VPK

Entry DOI	10.2210/pdb3vpk/pdb
Descriptor	Cationic trypsin, 6-carbamimidamidohexanoic acid, CALCIUM ION, ... (5 entities in total)
Functional Keywords	acyl-enzyme intermediate, serine protease inhibitor, trypsin, serine protease, digestion, anti-pancreatitis drug, leaving group, catalytic water molecule, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Bos taurus (bovine)
Cellular location	Secreted, extracellular space: P00760
Total number of polymer chains	1
Total formula weight	23703.75
Authors	Masuda, Y.,Nitanai, Y.,Mizutani, R.,Noguchi, S. (deposition date: 2012-03-05, release date: 2012-05-23, Last modification date: 2013-02-06)
Primary citation	Masuda, Y.,Nitanai, Y.,Mizutani, R.,Noguchi, S. Crystal structure of 6-guanidinohexanoyl trypsin near the optimum pH reveals the acyl-enzyme intermediate to be deacylated Proteins, 2012 Cited by PubMed: 23161653 DOI: 10.1002/prot.24206 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation