3VPK

Crystal Structure of 6-Guanidinohexanoyl Trypsin

3VPK の概要

• エントリーDOI: 10.2210/pdb3vpk/pdb
• 分子名称: Cationic trypsin, 6-carbamimidamidohexanoic acid, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: acyl-enzyme intermediate, serine protease inhibitor, trypsin, serine protease, digestion, anti-pancreatitis drug, leaving group, catalytic water molecule, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Bos taurus (bovine)
• 細胞内の位置: Secreted, extracellular space: P00760
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23703.75

構造登録者

Masuda, Y.,Nitanai, Y.,Mizutani, R.,Noguchi, S. (登録日: 2012-03-05, 公開日: 2012-05-23, 最終更新日: 2013-02-06)

• 主引用文献: Masuda, Y.,Nitanai, Y.,Mizutani, R.,Noguchi, S.; Crystal structure of 6-guanidinohexanoyl trypsin near the optimum pH reveals the acyl-enzyme intermediate to be deacylated; Proteins, 2012; PubMed: 23161653; DOI: 10.1002/prot.24206

実験手法

X-RAY DIFFRACTION (1.94 Å)