3VP2

Crystal structure of human glutaminase in complex with inhibitor 2

3VP2 の概要

• エントリーDOI: 10.2210/pdb3vp2/pdb
• 関連するPDBエントリー: 3VOY 3VP0 3VP1 3VP3 3VP4 3VPZ
• 分子名称: Glutaminase kidney isoform, mitochondrial, 5,5'-(sulfanediyldiethane-2,1-diyl)bis(1,3,4-thiadiazol-2-amine), SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Cytoplasm, cytosol. Isoform 3: Mitochondrion: O94925
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35073.09

構造登録者

Thangavelu, K.,Sivaraman, J. (登録日: 2012-02-23, 公開日: 2012-06-13, 最終更新日: 2023-11-08)

• 主引用文献: Thangavelu, K.,Pan, C.Q.,Karlberg, T.,Balaji, G.,Uttamchandani, M.,Suresh, V.,Schuler, H.,Low, B.C.,Sivaraman, J.; Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.; Proc.Natl.Acad.Sci.USA, 109:7705-7710, 2012; PubMed: 22538822; DOI: 10.1073/pnas.1116573109

実験手法

X-RAY DIFFRACTION (2.7 Å)