3VO3
Crystal Structure of the Kinase domain of Human VEGFR2 with imidazo[1,2-b]pyridazine derivative
Summary for 3VO3
Entry DOI | 10.2210/pdb3vo3/pdb |
Related | 3VHE |
Descriptor | Vascular endothelial growth factor receptor 2, N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | vegfr2, kinase domain, tyrosin-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted (Probable). Isoform 3: Secreted: P35968 |
Total number of polymer chains | 1 |
Total formula weight | 36846.39 |
Authors | |
Primary citation | Miyamoto, N.,Sakai, N.,Hirayama, T.,Miwa, K.,Oguro, Y.,Oki, H.,Okada, K.,Takagi, T.,Iwata, H.,Awazu, Y.,Yamasaki, S.,Takeuchi, T.,Miki, H.,Hori, A.,Imamura, S. Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor Bioorg.Med.Chem., 21:2333-2345, 2013 Cited by PubMed: 23498918DOI: 10.1016/j.bmc.2013.01.074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.52 Å) |
Structure validation
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