3VN4

Crystal structure of the exosite-containing fragment of human ADAMTS13 (P475S mutant)

Summary for 3VN4

• Entry DOI: 10.2210/pdb3vn4/pdb
• Related: 3GHM 3GHN
• Descriptor: A disintegrin and metalloproteinase with thrombospondin motifs 13, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose, ... (6 entities in total)
• Functional Keywords: hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 46491.21

Authors

Nakayama, D.,Akiyama, M.,Takeda, S.,Kokame, K.,Takagi, J.,Miyata, T. (deposition date: 2011-12-21, release date: 2012-12-26, Last modification date: 2024-07-31)

Primary citation

Akiyama, M.,Nakayama, D.,Takeda, S.,Kokame, K.,Takagi, J.,Miyata, T.
Crystal structure and enzymatic activity of an ADAMTS-13 mutant with the East Asian-specific P475S polymorphism.
J.Thromb.Haemost., 11:1399-1406, 2013

PubMed Abstract: An East Asian-specific P475S polymorphism in the gene encoding ADAMTS-13 causes an approximately 16% reduction in plasma ADAMTS-13 activity.

PubMed: 23621748
DOI: 10.1111/jth.12279

Experimental method

X-RAY DIFFRACTION (2.8 Å)