3VMT

Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a Lipid II analog

Summary for 3VMT

• Entry DOI: 10.2210/pdb3vmt/pdb
• Related: 3VMQ 3VMR 3VMS
• Descriptor: Monofunctional glycosyltransferase, [(2R,3R,4R,5S,6R)-4-[(2R)-1-[[(2S)-1-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxidanylidene-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethylamino]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-propan-2-yl]oxy-3-acetamido-5-[(2S,3R,4R,5R,6R)-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxan-2-yl] [oxidanyl(3,7,11,15,19,23,27,31,35,39,43-undecamethyltetratetraconta-2,6,10,14,18,22,26,30,34,38,42-undecaenoxy)phosphoryl] hydrogen phosphate, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: transmembrane, glycosyltransferase, bacterial cell wall synthesis, membrane, transferase
• Biological source: Staphylococcus aureus
• Cellular location: Cell membrane; Single-pass membrane protein (By similarity): Q99T05
• Total number of polymer chains: 2
• Total formula weight: 62510.62

Authors

Huang, C.Y.,Shih, H.W.,Lin, L.Y.,Tien, Y.W.,Cheng, T.J.R.,Cheng, W.C.,Wong, C.H.,Ma, C. (deposition date: 2011-12-15, release date: 2012-04-18, Last modification date: 2023-11-08)

• Primary citation: Huang, C.Y.,Shih, H.W.,Lin, L.Y.,Tien, Y.W.,Cheng, T.J.R.,Cheng, W.C.,Wong, C.H.,Ma, C.; Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism; Proc.Natl.Acad.Sci.USA, 109:6496-6501, 2012; PubMed: 22493270; DOI: 10.1073/pnas.1203900109

Experimental method

X-RAY DIFFRACTION (2.299 Å)