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3VJM

Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with a prolylthiazolidine inhibitor #1

3VJM の概要
エントリーDOI10.2210/pdb3vjm/pdb
関連するPDBエントリー3VJK 3VJL
分子名称Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 1,3-thiazolidin-3-yl[(2S,4S)-4-{4-[2-(trifluoromethyl)quinolin-4-yl]piperazin-1-yl}pyrrolidin-2-yl]methanone, ... (5 entities in total)
機能のキーワードalpha/beta, beta-propeller, aminopeptidase, serine protease, signal-anchor, transmembrane, diabetes, glycoprotein, cell membrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
由来する生物種Homo sapiens (human)
タンパク質・核酸の鎖数2
化学式量合計176361.59
構造登録者
Akahoshi, F.,Kishida, H.,Miyaguchi, I.,Yoshida, T.,Ishii, S. (登録日: 2011-10-24, 公開日: 2012-08-15, 最終更新日: 2023-11-08)
主引用文献Yoshida, T.,Akahoshi, F.,Sakashita, H.,Sonda, S.,Takeuchi, M.,Tanaka, Y.,Nabeno, M.,Kishida, H.,Miyaguchi, I.,Hayashi, Y.
Fused bicyclic heteroarylpiperazine-substituted l-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group
Bioorg.Med.Chem., 20:5033-5041, 2012
Cited by
PubMed: 22824762
DOI: 10.1016/j.bmc.2012.06.033
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.1 Å)
構造検証レポート
Validation report summary of 3vjm
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-07-31に公開中

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