3VI8
Human PPAR alpha ligand binding domain in complex with a synthetic agonist APHM13
Summary for 3VI8
Entry DOI | 10.2210/pdb3vi8/pdb |
Related | 2znn |
Descriptor | Peroxisome proliferator-activated receptor alpha, (2S)-2-(4-methoxy-3-{[(pyren-1-ylcarbonyl)amino]methyl}benzyl)butanoic acid (3 entities in total) |
Functional Keywords | nuclear receptor, protein-ligand complex, ppar, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q07869 |
Total number of polymer chains | 1 |
Total formula weight | 31321.59 |
Authors | Oyama, T.,Miyachi, H.,Morikawa, K. (deposition date: 2011-09-25, release date: 2012-08-29, Last modification date: 2023-11-08) |
Primary citation | Kuwabara, N.,Oyama, T.,Tomioka, D.,Ohashi, M.,Yanagisawa, J.,Shimizu, T.,Miyachi, H. Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype J.Med.Chem., 55:893-902, 2012 Cited by PubMed: 22185225DOI: 10.1021/jm2014293 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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