3VHW

Crystal structure of the human vitamin D receptor ligand binding domain complexed with 4-MP

Summary for 3VHW

Entry DOI	10.2210/pdb3vhw/pdb
Descriptor	Vitamin D3 receptor, methyl (1S,3E)-3-{(2R)-2-[(1R,3aS,4E,7aR)-4-{(2Z)-2-[(3R,4S,5R)-3,5-dihydroxy-4-(3-hydroxypropoxy)-2-methylidenecyclohexylidene]ethylidene}-7a-methyloctahydro-1H-inden-1-yl]propylidene}-1-ethyl-2-oxocyclopentanecarboxylate (non-preferred name) (3 entities in total)
Functional Keywords	hormone receptor, transcription
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P11473
Total number of polymer chains	1
Total formula weight	30376.10
Authors	Kakuda, S.,Takimoto-Kamimura, M. (deposition date: 2011-09-08, release date: 2013-03-06, Last modification date: 2023-11-08)
Primary citation	Saito, H.,Takagi, K.,Horie, K.,Kakuda, S.,Takimoto-Kamimura, M.,Ochiai, E.,Chida, T.,Harada, Y.,Takenouchi, K.,Kittaka, A. Synthesis of novel C-2 substituted vitamin D derivatives having ringed side chains and their biological evaluation on bone J.Steroid Biochem.Mol.Biol., 136:3-8, 2013 Cited by PubMed: 23416104 DOI: 10.1016/j.jsbmb.2013.02.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.43 Å)

Structure validation