3VHU
Mineralocorticoid receptor ligand-binding domain with spironolactone
Summary for 3VHU
Entry DOI | 10.2210/pdb3vhu/pdb |
Related | 2AB2 2OAX 3VHV |
Descriptor | Mineralocorticoid receptor, SPIRONOLACTONE (3 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, activating mutation, hypertension, antagonist, spironolactone, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P08235 |
Total number of polymer chains | 1 |
Total formula weight | 34422.79 |
Authors | Sogabe, S.,Habuka, N. (deposition date: 2011-09-07, release date: 2011-12-28, Last modification date: 2023-11-08) |
Primary citation | Hasui, T.,Matsunaga, N.,Ora, T.,Ohyabu, N.,Nishigaki, N.,Imura, Y.,Igata, Y.,Matsui, H.,Motoyaji, T.,Tanaka, T.,Habuka, N.,Sogabe, S.,Ono, M.,Siedem, C.S.,Tang, T.P.,Gauthier, C.,De Meese, L.A.,Boyd, S.A.,Fukumoto, S. Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists J.Med.Chem., 54:8616-8631, 2011 Cited by PubMed: 22074142DOI: 10.1021/jm2011645 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
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