3VDX

Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains

3VDX の概要

• エントリーDOI: 10.2210/pdb3vdx/pdb
• 関連するPDBエントリー: 4D9J
• 分子名称: Designed 16nm tetrahedral protein cage containing Non-haem bromoperoxidase BPO-A2 and Matrix protein 1 (1 entity in total)
• 機能のキーワード: protein design, bionanotechnology, protein assembly, symmetry, biomaterials, de novo protein
• 由来する生物種: Streptomyces aureofaciens; 詳細
• 細胞内の位置: Virion membrane ; Peripheral membrane protein ; Cytoplasmic side : P03485
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 150793.24

構造登録者

Lai, Y.-T.,Cascio, D.,Yeates, T.O. (登録日: 2012-01-06, 公開日: 2012-06-20, 最終更新日: 2023-09-13)

主引用文献

Lai, Y.T.,Cascio, D.,Yeates, T.O.
Structure of a 16-nm cage designed by using protein oligomers.
Science, 336:1129-1129, 2012

PubMed Abstract: Designing protein molecules that will assemble into various kinds of ordered materials represents an important challenge in nanotechnology. We report the crystal structure of a 12-subunit protein cage that self-assembles by design to form a tetrahedral structure roughly 16 nanometers in diameter. The strategy of fusing together oligomeric protein domains can be generalized to produce other kinds of cages or extended materials.

PubMed: 22654051
DOI: 10.1126/science.1219351

実験手法

X-RAY DIFFRACTION (3.002 Å)