3VDD
Structure of HRV2 capsid complexed with antiviral compound BTA798
3VDD の概要
エントリーDOI | 10.2210/pdb3vdd/pdb |
分子名称 | Protein VP1, Protein VP2, Protein VP3, ... (6 entities in total) |
機能のキーワード | viral capsid, virus-drug complex, virus |
由来する生物種 | Human rhinovirus 2 (HRV-2) 詳細 |
細胞内の位置 | Capsid protein VP0: Virion (By similarity). Capsid protein VP4: Virion (By similarity). Capsid protein VP2: Virion (By similarity). Capsid protein VP3: Virion (By similarity). Capsid protein VP1: Virion (By similarity). Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3AB: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Viral protein genome-linked: Virion (By similarity). Protease 3C: Host cytoplasm (By similarity). Protein 3CD: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). RNA-directed RNA polymerase: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P04936 P04936 P04936 P04936 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 95262.10 |
構造登録者 | |
主引用文献 | Feil, S.C.,Hamilton, S.,Krippner, G.Y.,Lin, B.,Luttick, A.,McConnell, D.B.,Nearn, R.,Parker, M.W.,Ryan, J.,Stanislawski, P.C.,Tucker, S.P.,Watson, K.G.,Morton, C.J. An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus. ACS Med Chem Lett, 3:303-307, 2012 Cited by PubMed: 24900468DOI: 10.1021/ml2002955 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.2 Å) |
構造検証レポート
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