3VC4
Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
Summary for 3VC4
Entry DOI | 10.2210/pdb3vc4/pdb |
Related | 3VBQ 3VBT 3VBV 3VBW 3VBX 3VBY |
Descriptor | Serine/threonine-protein kinase pim-1, IMIDAZOLE, (5Z)-5-[3-(trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione, ... (4 entities in total) |
Functional Keywords | pim1, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
Total number of polymer chains | 1 |
Total formula weight | 34892.49 |
Authors | |
Primary citation | Good, A.C.,Liu, J.,Hirth, B.,Asmussen, G.,Xiang, Y.,Biemann, H.P.,Bishop, K.A.,Fremgen, T.,Fitzgerald, M.,Gladysheva, T.,Jain, A.,Jancsics, K.,Metz, M.,Papoulis, A.,Skerlj, R.,Stepp, J.D.,Wei, R.R. Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55:2641-2648, 2012 Cited by PubMed: 22339127DOI: 10.1021/jm2014698 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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