3VA4

Crystal structure of the mammalian MDC1 FHA domain complexed with CHK2 pThr68 peptide

Summary for 3VA4

• Entry DOI: 10.2210/pdb3va4/pdb
• Related: 3VA1
• Descriptor: Mediator of DNA damage checkpoint protein 1, Serine/threonine-protein kinase Chk2 (3 entities in total)
• Functional Keywords: cell cycle, fha domain, dna-damage, chk2 and mdc1 dimerization
• Biological source: Mus musculus; More
• Cellular location: Nucleus: Q5PSV9; Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
• Total number of polymer chains: 3
• Total formula weight: 30528.76

Authors

Wu, H.H.,Wu, P.Y.,Huang, K.F.,Kao, Y.Y.,Tsai, M.D. (deposition date: 2011-12-28, release date: 2012-02-01)

• Primary citation: Wu, H.H.,Wu, P.Y.,Huang, K.F.,Kao, Y.Y.,Tsai, M.D.; Structural Delineation of MDC1-FHA Domain Binding with CHK2-pThr68.; Biochemistry, 2012; PubMed: 22211259; DOI: 10.1021/bi201709w

Experimental method

X-RAY DIFFRACTION (1.54 Å)