3V8F

Crystal structure of crosslinked GltPh V216C-M385C mutant

3V8F の概要

• エントリーDOI: 10.2210/pdb3v8f/pdb
• 関連するPDBエントリー: 1XFH 2NWL 2NWW 2NWX 3KBC 3V8G
• 分子名称: sodium-coupled L-aspartate transporter, ASPARTIC ACID, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: sodium ions, l-arpartate, membrane, transport protein
• 由来する生物種: Pyrococcus horikoshii
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 134896.54

構造登録者

Verdon, G.,Boudker, O. (登録日: 2011-12-22, 公開日: 2012-02-15, 最終更新日: 2024-02-28)

主引用文献

Verdon, G.,Boudker, O.
Crystal structure of an asymmetric trimer of a bacterial glutamate transporter homolog.
Nat.Struct.Mol.Biol., 19:355-357, 2012

PubMed Abstract: We report a structure of a trimeric glutamate transporter homolog from Pyrococcus horikoshii with two protomers in an inward facing state and the third in an intermediate conformation between the outward and inward facing states. The intermediate shows a cavity in the thinnest region of the transporter, which is potentially accessible to extracellular and cytoplasmic solutions. Our findings suggest a structural principle by which transport intermediates may mediate uncoupled permeation of polar solutes.

PubMed: 22343718
DOI: 10.1038/nsmb.2233

実験手法

X-RAY DIFFRACTION (3.8 Å)