3V72

Crystal Structure of Rat DNA polymerase beta Mutator E295K: Enzyme-dsDNA

Summary for 3V72

• Entry DOI: 10.2210/pdb3v72/pdb
• Related: 3V73
• Descriptor: DNA polymerase beta, DNA 5'-D(P*AP*TP*GP*TP*GP*AP*GP*T)-3', DNA 5'-D(P*AP*AP*AP*CP*TP*CP*AP*CP*AP*T)-3', ... (6 entities in total)
• Functional Keywords: dna repair polymerase, e295k, mutator, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Rattus norvegicus (rat); More
• Cellular location: Nucleus: P06766
• Total number of polymer chains: 3
• Total formula weight: 43984.37

Authors

Gridley, C.L.,Jaeger, J. (deposition date: 2011-12-20, release date: 2012-07-04, Last modification date: 2024-02-28)

• Primary citation: Li, Y.,Gridley, C.L.,Jaeger, J.,Sweasy, J.B.,Schlick, T.; Unfavorable Electrostatic and Steric Interactions in DNA Polymerase beta E295K Mutant Interfere with the Enzyme s Pathway; J.Am.Chem.Soc., 134:9999-10010, 2012; PubMed: 22651551; DOI: 10.1021/ja300361r

Experimental method

X-RAY DIFFRACTION (2.49 Å)