3V6O
Leptin Receptor-antibody complex
Summary for 3V6O
Entry DOI | 10.2210/pdb3v6o/pdb |
Descriptor | Leptin receptor, Monoclonal antibody 9F8 fab fragment Heavy chain, Monoclonal antibody 9F8 fab fragment Light chain, ... (9 entities in total) |
Functional Keywords | receptor-antibody complex, cytokine receptor, antibody fab fragment, immunoglobulin fold, leptin receptor-antibody complex, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 144456.21 |
Authors | Carpenter, B.,Hemsworth, G.R.,Ross, R.J.,Artymiuk, P.J. (deposition date: 2011-12-20, release date: 2012-03-14, Last modification date: 2024-10-16) |
Primary citation | Carpenter, B.,Hemsworth, G.R.,Wu, Z.,Maamra, M.,Strasburger, C.J.,Ross, R.J.,Artymiuk, P.J. Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody. Structure, 20:487-497, 2012 Cited by PubMed: 22405007DOI: 10.1016/j.str.2012.01.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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