3V6O

Leptin Receptor-antibody complex

3V6O の概要

• エントリーDOI: 10.2210/pdb3v6o/pdb
• 分子名称: Leptin receptor, Monoclonal antibody 9F8 fab fragment Heavy chain, Monoclonal antibody 9F8 fab fragment Light chain, ... (9 entities in total)
• 機能のキーワード: receptor-antibody complex, cytokine receptor, antibody fab fragment, immunoglobulin fold, leptin receptor-antibody complex, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 144456.21

構造登録者

Carpenter, B.,Hemsworth, G.R.,Ross, R.J.,Artymiuk, P.J. (登録日: 2011-12-20, 公開日: 2012-03-14, 最終更新日: 2023-12-27)

• 主引用文献: Carpenter, B.,Hemsworth, G.R.,Wu, Z.,Maamra, M.,Strasburger, C.J.,Ross, R.J.,Artymiuk, P.J.; Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody.; Structure, 20:487-497, 2012; PubMed: 22405007; DOI: 10.1016/j.str.2012.01.019

実験手法

X-RAY DIFFRACTION (1.95 Å)