3V5Q

Discovery of a selective TRK Inhibitor with efficacy in rodent cancer tumor models

3V5Q の概要

• エントリーDOI: 10.2210/pdb3v5q/pdb
• 分子名称: NT-3 growth factor receptor, CHLORIDE ION, 1-(3-{[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-6-yl]amino}phenyl)-3-[3-(trifluoromethyl)phenyl]urea, ... (4 entities in total)
• 機能のキーワード: kinase domain, kinase, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: Q16288
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68923.39

構造登録者

Kreusch, A. (登録日: 2011-12-16, 公開日: 2012-02-08, 最終更新日: 2024-02-28)

• 主引用文献: Albaugh, P.,Fan, Y.,Mi, Y.,Sun, F.,Adrian, F.,Li, N.,Jia, Y.,Sarkisova, Y.,Kreusch, A.,Hood, T.,Lu, M.,Liu, G.,Huang, S.,Liu, Z.,Loren, J.,Tuntland, T.,Karanewsky, D.S.,Seidel, H.M.,Molteni, V.; Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.; ACS Med Chem Lett, 3:140-145, 2012; PubMed: 24900443; DOI: 10.1021/ml200261d

実験手法

X-RAY DIFFRACTION (2.2001 Å)