3V4X

The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthase, mvaS, by Hymeglusin

3V4X の概要

• エントリーDOI: 10.2210/pdb3v4x/pdb
• 関連するPDBエントリー: 3V4N
• 分子名称: HMG-CoA synthase, (7R,12R,13R)-13-formyl-12,14-dihydroxy-3,5,7-trimethyltetradeca-2,4-dienoic acid (3 entities in total)
• 機能のキーワード: hydroxymethylglutaryl-coa synthase, hymeglusin covalent adduct, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Enterococcus faecalis
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 171693.45

構造登録者

Skaff, D.A.,Ramyar, K.X.,McWhorter, W.J.,Geisbrecht, B.V.,Miziorko, H.M. (登録日: 2011-12-15, 公開日: 2012-04-25, 最終更新日: 2023-09-13)

• 主引用文献: Skaff, D.A.,Ramyar, K.X.,McWhorter, W.J.,Barta, M.L.,Geisbrecht, B.V.,Miziorko, H.M.; Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin.; Biochemistry, 51:4713-4722, 2012; PubMed: 22510038; DOI: 10.1021/bi300037k

実験手法

X-RAY DIFFRACTION (1.952 Å)