3V4K
First-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase APOBEC3G
Summary for 3V4K
Entry DOI | 10.2210/pdb3v4k/pdb |
Related | 3V4J |
Descriptor | DNA dC->dU-editing enzyme APOBEC-3G, CHLORIDE ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | apobec3g, antiviral defense, host-virus interaction, hydrolase, metal-binding, nucleus |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q9HC16 |
Total number of polymer chains | 2 |
Total formula weight | 47650.50 |
Authors | Shandilya, S.M.D.,Ali, A.,Schiffer, C.A. (deposition date: 2011-12-15, release date: 2012-01-25, Last modification date: 2023-09-13) |
Primary citation | Li, M.,Shandilya, S.M.,Carpenter, M.A.,Rathore, A.,Brown, W.L.,Perkins, A.L.,Harki, D.A.,Solberg, J.,Hook, D.J.,Pandey, K.K.,Parniak, M.A.,Johnson, J.R.,Krogan, N.J.,Somasundaran, M.,Ali, A.,Schiffer, C.A.,Harris, R.S. First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G. Acs Chem.Biol., 7:506-517, 2012 Cited by PubMed: 22181350DOI: 10.1021/cb200440y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.38 Å) |
Structure validation
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