3V3L

Crystal structure of human RNF146 WWE domain in complex with iso-ADPRibose

Summary for 3V3L

• Entry DOI: 10.2210/pdb3v3l/pdb
• Descriptor: E3 ubiquitin-protein ligase RNF146, 2'-O-(5-O-phosphono-alpha-D-ribofuranosyl)adenosine 5'-(dihydrogen phosphate) (3 entities in total)
• Functional Keywords: ligase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytosol: Q9NTX7
• Total number of polymer chains: 2
• Total formula weight: 21629.09

Authors

Wang, Z.,Cheng, Z.,Xu, W. (deposition date: 2011-12-13, release date: 2012-02-15)

• Primary citation: Wang, Z.,Michaud, G.A.,Cheng, Z.,Zhang, Y.,Hinds, T.R.,Fan, E.,Cong, F.,Xu, W.; Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination.; Genes Dev., 26:235-240, 2012; PubMed: 22267412; DOI: 10.1101/gad.182618.111

Experimental method

X-RAY DIFFRACTION (1.65 Å)