3V10

Crystal structure of the collagen binding domain of Erysipelothrix rhusiopathiae surface protein RspB

3V10 の概要

• エントリーDOI: 10.2210/pdb3v10/pdb
• 関連するPDBエントリー: 2f6a 2z1p
• 分子名称: Rhusiopathiae surface protein B (2 entities in total)
• 機能のキーワード: rhusiopathiae surface protein b, collagen hug model, dev-igg fold, collagen binding protein, cell adhesion
• 由来する生物種: Erysipelothrix rhusiopathiae
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71401.75

構造登録者

Ponnuraj, K.,Swarmistha devi, A.,Ogawa, Y.,Shimoji, Y.,Subramainan, B. (登録日: 2011-12-09, 公開日: 2012-10-24, 最終更新日: 2024-03-20)

主引用文献

Devi, A.S.,Ogawa, Y.,Shimoji, Y.,Balakumar, S.,Ponnuraj, K.
Collagen adhesin-nanoparticle interaction impairs adhesin's ligand binding mechanism
Biochim.Biophys.Acta, 1820:819-828, 2012

PubMed Abstract: Pathogenic bacteria specifically recognize extracellular matrix (ECM) molecules of the host (e.g. collagen, fibrinogen and fibronectin) through their surface proteins known as MSCRAMMs (Microbial Surface Components Recognizing Adhesive Matrix Molecules) and initiate colonization. On implantation, biomaterials easily get coated with these ECM molecules and the MSCRAMMs mediate bacterial adherence to biomaterials. With the rapid rise in antibiotic resistance, designing alternative strategies to reduce/eliminate bacterial colonization is absolutely essential.

PubMed: 22538248
DOI: 10.1016/j.bbagen.2012.04.006

実験手法

X-RAY DIFFRACTION (1.75 Å)