3V0W

Crystal structure of Fab WN1 222-5 in complex with LPS

3V0W の概要

• エントリーDOI: 10.2210/pdb3v0w/pdb
• 分子名称: WN1 222-5 Fab (IgG2a) light chain, WN1 222-5 Fab (IgG2a) heavy chain, 2-amino-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-glucopyranose-(1-2)-alpha-D-glucopyranose-(1-3)-[alpha-D-galactopyranose-(1-6)]alpha-D-glucopyranose-(1-3)-[L-glycero-alpha-D-manno-heptopyranose-(1-7)]4-O-phosphono-L-glycero-alpha-D-manno-heptopyranose-(1-3)-4-O-phosphono-L-glycero-alpha-D-manno-heptopyranose-(1-5)-[3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)]3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, ... (5 entities in total)
• 機能のキーワード: beta barrel, antibody, fab, immune system
• 由来する生物種: Mus musculus (mouse); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49644.15

構造登録者

Gomery, K.,Evans, S.V. (登録日: 2011-12-08, 公開日: 2012-12-05, 最終更新日: 2020-07-29)

• 主引用文献: Gomery, K.,Muller-Loennies, S.,Brooks, C.L.,Brade, L.,Kosma, P.,Di Padova, F.,Brade, H.,Evans, S.V.; Antibody WN1 222-5 mimics Toll-like receptor 4 binding in the recognition of LPS.; Proc.Natl.Acad.Sci.USA, 109:20877-20882, 2012; PubMed: 23184990; DOI: 10.1073/pnas.1209253109

実験手法

X-RAY DIFFRACTION (1.73 Å)