3UZV

Crystal structure of the dengue virus serotype 2 envelope protein domain III in complex with the variable domains of Mab 4E11

3UZV の概要

• エントリーDOI: 10.2210/pdb3uzv/pdb
• 関連するPDBエントリー: 3UYP 3UZE 3UZQ
• 分子名称: envelope protein, anti-dengue Mab 4E11, ETHANOL, ... (4 entities in total)
• 機能のキーワード: dengue antibody neutralization, immune system
• 由来する生物種: Dengue virus 2 (DENV-2); 詳細
• 細胞内の位置: Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P07564
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40159.09

構造登録者

Cockburn, J.J.B.,Navarro Sanchez, M.E.,Fretes, N.,Urvoas, A.,Staropoli, I.,Kikuti, C.M.,Coffey, L.L.,Arenzana Seisdedos, F.,Bedouelle, H.,Rey, F.A. (登録日: 2011-12-07, 公開日: 2012-02-22, 最終更新日: 2023-09-13)

• 主引用文献: Cockburn, J.J.,Navarro Sanchez, M.E.,Fretes, N.,Urvoas, A.,Staropoli, I.,Kikuti, C.M.,Coffey, L.L.,Arenzana Seisdedos, F.,Bedouelle, H.,Rey, F.A.; Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody.; Structure, 20:303-314, 2012; PubMed: 22285214; DOI: 10.1016/j.str.2012.01.001

実験手法

X-RAY DIFFRACTION (2.1 Å)