3UYH

Crystal structure of an intramolecular human telomeric DNA G-quadruplex bound by the naphthalene diimide compound, MM41

Summary for 3UYH

Entry DOI	10.2210/pdb3uyh/pdb
Related	3CCO 3CDM 3SC8 3T5E
Descriptor	human telomeric DNA sequence, POTASSIUM ION, 4,9-bis{[3-(4-methylpiperazin-1-yl)propyl]amino}-2,7-bis[3-(morpholin-4-yl)propyl]benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetrone, ... (4 entities in total)
Functional Keywords	intramolecular, ligand-complex, g-quadruplex, telomere, dna
Biological source	Synthetic DNA
Total number of polymer chains	1
Total formula weight	7931.85
Authors	Collie, G.W.,Neidle, S. (deposition date: 2011-12-06, release date: 2013-01-02, Last modification date: 2023-09-13)
Primary citation	Micco, M.,Collie, G.W.,Dale, A.G.,Ohnmacht, S.A.,Pazitna, I.,Gunaratnam, M.,Reszka, A.P.,Neidle, S. Structure-based design and evaluation of naphthalene diimide g-quadruplex ligands as telomere targeting agents in pancreatic cancer cells. J.Med.Chem., 56:2959-2974, 2013 Cited by PubMed: 23514618 DOI: 10.1021/jm301899y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation