3UVV

Crystal Structure of the ligand binding domains of the thyroid receptor:retinoid X receptor complexed with 3,3',5 triiodo-L-thyronine and 9-cis retinoic acid

3UVV の概要

• エントリーDOI: 10.2210/pdb3uvv/pdb
• 分子名称: Thyroid hormone receptor alpha, Retinoic acid receptor RXR-alpha, 3,5,3'TRIIODOTHYRONINE, ... (5 entities in total)
• 機能のキーワード: tr-rxr heterodimer, allostery, alpha helical sandwich, transactivation, hormone receptor-hormone receptor complex, hormone receptor/hormone receptor
• 由来する生物種: Gallus gallus (bantam,chickens); 詳細
• 細胞内の位置: Nucleus: P04625 P19793
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58388.98

構造登録者

Fernandez, E.J.,Putcha, B.-D.K.,Wright, E.,Brunzelle, J.S. (登録日: 2011-11-30, 公開日: 2012-04-18, 最終更新日: 2023-11-15)

• 主引用文献: Putcha, B.D.,Wright, E.,Brunzelle, J.S.,Fernandez, E.J.; Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers.; Proc.Natl.Acad.Sci.USA, 109:6084-6087, 2012; PubMed: 22474364; DOI: 10.1073/pnas.1119852109

実験手法

X-RAY DIFFRACTION (2.95 Å)