3URQ

Crystal Structure of PTE mutant H254G/H257W/L303T/M317L/I106C/F132I/L271I/K185R/I274N/A80V/R67H with cyclohexyl methylphosphonate inhibitor

3URQ の概要

• エントリーDOI: 10.2210/pdb3urq/pdb
• 関連するPDBエントリー: 3UPM 3UR2 3UR3 3URA 3URB 3URN
• 分子名称: Parathion hydrolase, COBALT (II) ION, cyclohexyl methylphosphonate, ... (5 entities in total)
• 機能のキーワード: metalloenzyme, tim barrel, nerve agents, phosphotriesterase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Brevundimonas diminuta
• 細胞内の位置: Cell membrane; Peripheral membrane protein: P0A434
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71792.91

構造登録者

Tsai, P.,Fox, N.G.,Li, Y.,Barondeau, D.P.,Raushel, F.M. (登録日: 2011-11-22, 公開日: 2012-08-01, 最終更新日: 2023-12-06)

• 主引用文献: Tsai, P.C.,Fox, N.,Bigley, A.N.,Harvey, S.P.,Barondeau, D.P.,Raushel, F.M.; Enzymes for the homeland defense: optimizing phosphotriesterase for the hydrolysis of organophosphate nerve agents.; Biochemistry, 51:6463-6475, 2012; PubMed: 22809162; DOI: 10.1021/bi300811t

実験手法

X-RAY DIFFRACTION (2.1 Å)