3UPX

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1300

3UPX の概要

• エントリーDOI: 10.2210/pdb3upx/pdb
• 関連するPDBエントリー: 3UPZ 3UQF 3UQG 3V51 3V5P 3V5T
• 分子名称: Calmodulin-domain protein kinase 1, [2-amino-1-(piperidin-4-ylmethyl)-1H-benzimidazol-6-yl](phenyl)methanone (3 entities in total)
• 機能のキーワード: serine/threonine protein kinase, transferase, calcium-binding, atp-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Toxoplasma gondii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 55561.33

構造登録者

Merritt, E.A.,Larson, E.T. (登録日: 2011-11-18, 公開日: 2012-03-14, 最終更新日: 2024-02-28)

• 主引用文献: Larson, E.T.,Ojo, K.K.,Murphy, R.C.,Johnson, S.M.,Zhang, Z.,Kim, J.E.,Leibly, D.J.,Fox, A.M.,Reid, M.C.,Dale, E.J.,Perera, B.G.,Kim, J.,Hewitt, S.N.,Hol, W.G.,Verlinde, C.L.,Fan, E.,Van Voorhis, W.C.,Maly, D.J.,Merritt, E.A.; Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1.; J.Med.Chem., 55:2803-2810, 2012; PubMed: 22369268; DOI: 10.1021/jm201725v

実験手法

X-RAY DIFFRACTION (2.27 Å)