3UPR

HLA-B*57:01 complexed to pep-V and Abacavir

3UPR の概要

• エントリーDOI: 10.2210/pdb3upr/pdb
• 関連するPDBエントリー: 2BVO 2BVP 2HJL 2RFX
• 分子名称: HLA class I histocompatibility antigen, B-57 alpha chain, pep-V, Beta-2-microglobulin, ... (6 entities in total)
• 機能のキーワード: hla-b*57:01, mhc, antigen presenting cell, t-cell receptor, human leukocyte antigen, drug hypersensitivity, abacavir hypersensitivity, repertoire-altering small molecule, immune response, immunoglobulin-like beta-sandwich, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P18465; Secreted: P61769
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 89961.09

構造登録者

Pompeu, Y.A.,Ostrov, D.A. (登録日: 2011-11-18, 公開日: 2012-06-13, 最終更新日: 2023-09-13)

• 主引用文献: Ostrov, D.A.,Grant, B.J.,Pompeu, Y.A.,Sidney, J.,Harndahl, M.,Southwood, S.,Oseroff, C.,Lu, S.,Jakoncic, J.,de Oliveira, C.A.,Yang, L.,Mei, H.,Shi, L.,Shabanowitz, J.,English, A.M.,Wriston, A.,Lucas, A.,Phillips, E.,Mallal, S.,Grey, H.M.,Sette, A.,Hunt, D.F.,Buus, S.,Peters, B.; Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire.; Proc.Natl.Acad.Sci.USA, 109:9959-9964, 2012; PubMed: 22645359; DOI: 10.1073/pnas.1207934109

実験手法

X-RAY DIFFRACTION (1.999 Å)