3UMX

Crystal structure of Pim1 kinase in complex with inhibitor (Z)-2-[(1H-indol-3-yl)methylene]-7-(azepan-1-ylmethyl)-6-hydroxybenzofuran-3(2H)-one

3UMX の概要

• エントリーDOI: 10.2210/pdb3umx/pdb
• 関連するPDBエントリー: 3UIX 3UMW
• 分子名称: Proto-oncogene serine/threonine-protein kinase pim-1, (2Z)-7-(azepan-1-ylmethyl)-6-hydroxy-2-(1H-indol-3-ylmethylidene)-1-benzofuran-3(2H)-one, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: pim-1, kinase, p-loop, kinase inhibitor, rational drug design, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34672.25

構造登録者

Parker, L.J.,Handa, N.,Yokoyama, S. (登録日: 2011-11-15, 公開日: 2012-08-08, 最終更新日: 2023-11-01)

• 主引用文献: Parker, L.J.,Watanabe, H.,Tsuganezawa, K.,Tomabechi, Y.,Handa, N.,Shirouzu, M.,Yuki, H.,Honma, T.,Ogawa, N.,Nagano, T.,Yokoyama, S.,Tanaka, A.; Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor; Acta Crystallogr.,Sect.F, 68:860-866, 2012; PubMed: 22869110; DOI: 10.1107/S1744309112027108

実験手法

X-RAY DIFFRACTION (2.55 Å)