3UMW

Crystal structure of Pim1 kinase in complex with inhibitor (Z)-2-[(1H-indazol-3-yl)methylene]-6-methoxy-7-(piperazin-1-ylmethyl)benzofuran-3(2H)-one

Summary for 3UMW

Entry DOI	10.2210/pdb3umw/pdb
Related	3UIX 3UMX
Descriptor	Proto-oncogene serine/threonine-protein kinase pim-1, GLYCEROL, SULFATE ION, ... (5 entities in total)
Functional Keywords	pim1, kinase inhibitor, rational drug design, leukemia, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	34766.32
Authors	Parker, L.J.,Handa, N.,Yokoyama, S. (deposition date: 2011-11-14, release date: 2012-10-03, Last modification date: 2023-11-01)
Primary citation	Nakano, H.,Saito, N.,Parker, L.J.,Tada, Y.,Abe, M.,Tsuganezawa, K.,Yokoyama, S.,Tanaka, A.,Kojima, H.,Okabe, T.,Nagano, T. Rational evolution of a novel type of potent and selective proviral integration site in Moloney murine leukemia virus kinase 1 (PIM1) inhibitor from a screening-hit compound. J.Med.Chem., 55:5151-5164, 2012 Cited by PubMed: 22540945 DOI: 10.1021/jm3001289 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.08 Å)

Structure validation