3UMW

Crystal structure of Pim1 kinase in complex with inhibitor (Z)-2-[(1H-indazol-3-yl)methylene]-6-methoxy-7-(piperazin-1-ylmethyl)benzofuran-3(2H)-one

3UMW の概要

• エントリーDOI: 10.2210/pdb3umw/pdb
• 関連するPDBエントリー: 3UIX 3UMX
• 分子名称: Proto-oncogene serine/threonine-protein kinase pim-1, GLYCEROL, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: pim1, kinase inhibitor, rational drug design, leukemia, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34766.32

構造登録者

Parker, L.J.,Handa, N.,Yokoyama, S. (登録日: 2011-11-14, 公開日: 2012-10-03, 最終更新日: 2023-11-01)

• 主引用文献: Nakano, H.,Saito, N.,Parker, L.J.,Tada, Y.,Abe, M.,Tsuganezawa, K.,Yokoyama, S.,Tanaka, A.,Kojima, H.,Okabe, T.,Nagano, T.; Rational evolution of a novel type of potent and selective proviral integration site in Moloney murine leukemia virus kinase 1 (PIM1) inhibitor from a screening-hit compound.; J.Med.Chem., 55:5151-5164, 2012; PubMed: 22540945; DOI: 10.1021/jm3001289

実験手法

X-RAY DIFFRACTION (2.08 Å)