3ULL

HUMAN MITOCHONDRIAL SINGLE-STRANDED DNA BINDING PROTEIN

3ULL の概要

• エントリーDOI: 10.2210/pdb3ull/pdb
• 分子名称: DNA BINDING PROTEIN (2 entities in total)
• 機能のキーワード: dna-binding protein, dna replication, mitochondrion, transit peptide, dna binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion: Q04837
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30432.25

構造登録者

Yang, C.,Curth, U.,Urbanke, C.,Kang, C. (登録日: 1996-12-11, 公開日: 1997-10-15, 最終更新日: 2024-02-28)

主引用文献

Yang, C.,Curth, U.,Urbanke, C.,Kang, C.
Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4 A resolution.
Nat.Struct.Biol., 4:153-157, 1997

PubMed Abstract: We solved the crystal structure of the homotetrameric single-stranded DNA binding (SSB) protein from human mitochondria at a resolution of 2.4 A. The tetramer is formed by two dimers interacting head-to-head and shows D2 symmetry. Sequence-related tetrameric SSB proteins occur in prokaryotes and eukaryotic mitochondria; this is the first report of an atomic resolution structure of this type of protein. Using biochemical data and analysis of sequence homologies, we were able to correlate the functional properties with structure. We propose that ssDNA wraps around the tetrameric HsmtSSB protein through electropositive channels guided by flexible loops.

PubMed: 9033597
DOI: 10.1038/nsb0297-153

実験手法

X-RAY DIFFRACTION (2.4 Å)