3UKC

(S)-cEt-BNA decamer structure

3UKC の概要

• エントリーDOI: 10.2210/pdb3ukc/pdb
• 関連するPDBエントリー: 3UKB 3UKE
• 分子名称: DNA (5'-D(*GP*CP*GP*TP*AP*(1TL)P*AP*CP*GP*C)-3') (2 entities in total)
• 機能のキーワード: a-form dna, bicyclic nucleic acid, bna, dna, cet-bna, antisense oligonucleotides
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 6146.03

構造登録者

Pallan, P.S.,Egli, M. (登録日: 2011-11-09, 公開日: 2012-06-20, 最終更新日: 2023-09-13)

主引用文献

Pallan, P.S.,Allerson, C.R.,Berdeja, A.,Seth, P.P.,Swayze, E.E.,Prakash, T.P.,Egli, M.
Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
Chem.Commun.(Camb.), 48:8195-8197, 2012

PubMed Abstract: Combining the structural elements of the second generation 2'-O-methoxyethyl (MOE) and locked nucleic acid (LNA) antisense oligonucleotide (AON) modifications yielded the highly nuclease resistant 2',4'-constrained MOE and ethyl bicyclic nucleic acids (cMOE and cEt BNA, respectively). Crystal structures of DNAs with cMOE or cEt BNA residues reveal their conformational preferences. Comparisons with MOE and LNA structures allow insights into their favourable properties for AON applications.

PubMed: 22614180
DOI: 10.1039/c2cc32286b

実験手法

X-RAY DIFFRACTION (1.54 Å)