3UJM

Crystal structure of the NTF2-like domain of the Drosophila melanogaster Rasputin protein

3UJM の概要

• エントリーDOI: 10.2210/pdb3ujm/pdb
• 分子名称: Rasputin, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID (3 entities in total)
• 機能のキーワード: ntf2-like fold, ras signaling, signaling protein
• 由来する生物種: Drosophila melanogaster (Fruit fly)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28241.70

構造登録者

Vognsen, T.,Kristensen, O. (登録日: 2011-11-08, 公開日: 2012-04-25, 最終更新日: 2023-09-13)

主引用文献

Vognsen, T.,Kristensen, O.
Crystal structure of the Rasputin NTF2-like domain from Drosophila melanogaster.
Biochem.Biophys.Res.Commun., 420:188-192, 2012

PubMed Abstract: The crystal structure of the NTF2-like domain of the Drosophila homolog of Ras GTPase SH3 Binding Protein (G3BP), Rasputin, was determined at 2.7Å resolution. The overall structure is highly similar to nuclear transport factor 2: It is a homodimer comprised of a β-sheet and three α-helices forming a cone-like shape. However, known binding sites for RanGDP and FxFG containing peptides show electrostatic and steric differences compared to nuclear transport factor 2. A HEPES molecule bound in the structure suggests a new, and possibly physiologically relevant, ligand binding site.

PubMed: 22414690
DOI: 10.1016/j.bbrc.2012.02.140

実験手法

X-RAY DIFFRACTION (2.741 Å)