3UE8

Kynurenine Aminotransferase II Inhibitors

3UE8 の概要

• エントリーDOI: 10.2210/pdb3ue8/pdb
• 分子名称: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, (5-hydroxy-4-{[(1-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, CHLORIDE ION (3 entities in total)
• 機能のキーワード: kat ii, kynurenine aminotransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion : Q8N5Z0
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 99050.14

構造登録者

Dounay, A.B.,Anderson, M.,Bechle, B.M.,Campbell, B.M.,Claffey, M.M.,Evdokimov, A.,Edelweiss, E.,Fonseca, K.R.,Gan, X.,Ghosh, S.,Hayward, M.M.,Horner, W.,Kim, J.Y.,McAllister, L.A.,Pandit, J.,Paradis, V.,Parikh, V.D.,Reese, M.R.,Rong, S.B.,Salafia, M.A.,Schuyten, K.,Strick, C.A.,Tuttle, J.B.,Valentine, J.,Wang, H.,Zawadzke, L.E.,Verhoest, P.R. (登録日: 2011-10-28, 公開日: 2012-02-01, 最終更新日: 2024-02-28)

• 主引用文献: Dounay, A.B.,Anderson, M.,Bechle, B.M.,Campbell, B.M.,Claffey, M.M.,Evdokimov, A.,Evrard, E.,Fonseca, K.R.,Gan, X.,Ghosh, S.,Hayward, M.M.,Horner, W.,Kim, J.Y.,McAllister, L.A.,Pandit, J.,Paradis, V.,Parikh, V.D.,Reese, M.R.,Rong, S.,Salafia, M.A.,Schuyten, K.,Strick, C.A.,Tuttle, J.B.,Valentine, J.,Wang, H.,Zawadzke, L.E.,Verhoest, P.R.; Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.; ACS Med Chem Lett, 3:187-192, 2012; PubMed: 24900455; DOI: 10.1021/ml200204m

実験手法

X-RAY DIFFRACTION (3.22 Å)