3UE4

Structural and spectroscopic analysis of the kinase inhibitor bosutinib binding to the Abl tyrosine kinase domain

3UE4 の概要

• エントリーDOI: 10.2210/pdb3ue4/pdb
• 分子名称: Tyrosine-protein kinase ABL1, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile (3 entities in total)
• 機能のキーワード: protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67506.87

構造登録者

Boxer, S.G.,Levinson, N.M. (登録日: 2011-10-28, 公開日: 2012-04-18, 最終更新日: 2024-02-28)

• 主引用文献: Levinson, N.M.,Boxer, S.G.; Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the abl tyrosine kinase domain.; Plos One, 7:e29828-e29828, 2012; PubMed: 22493660; DOI: 10.1371/journal.pone.0029828

実験手法

X-RAY DIFFRACTION (2.424 Å)