3UDX

Crystal structure of Acinetobacter baumannii PBP1a in complex with Imipenem

Summary for 3UDX

• Entry DOI: 10.2210/pdb3udx/pdb
• Related: 3UDF 3UDI 3UE0 3UE1 3UE3
• Descriptor: Penicillin-binding protein 1a, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid (3 entities in total)
• Functional Keywords: transglycosylase, transpeptidase, penicillin-binding protein-antibiotic complex, penicillin-binding protein/antibiotic
• Biological source: Acinetobacter baumannii
• Total number of polymer chains: 2
• Total formula weight: 164376.52

Authors

Han, S. (deposition date: 2011-10-28, release date: 2011-12-14, Last modification date: 2013-06-26)

• Primary citation: Han, S.,Caspers, N.,Zaniewski, R.P.,Lacey, B.M.,Tomaras, A.P.,Feng, X.,Geoghegan, K.F.,Shanmugasundaram, V.; Distinctive attributes of beta-lactam target proteins in Acinetobacter baumannii relevant to development of new antibiotics; J.Am.Chem.Soc., 133:20536-20545, 2011; PubMed: 22050378; DOI: 10.1021/ja208835z

Experimental method

X-RAY DIFFRACTION (2.5 Å)